Stemolecule™ CHIR99021（GSK-3β抑制劑）

產(chǎn)品關鍵詞：

GSK-3β；na?ve stem cells 初始干細胞；neural progenitor cells 神經(jīng)祖細胞；WH-4-023；Y27632；PD0325901；CAS：252917-06-9；

產(chǎn)品描述：

氨基嘧啶CHIR99021是目前為止報道的選擇性zui強的GSK-3β抑制劑。與其他強效的GSK-3抑制劑相比，CHIR99021不會交叉抑制細胞周期蛋白依賴性激酶（CDKs），對GSK-3β的選擇性是對CDKs的350倍。與抑制MAPK來源的分化誘導信號聯(lián)合，使用CHIR99021阻斷 GSK-3β信號使得胚胎干細胞能自我更新。

產(chǎn)品特性

1. 同義名：6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2 pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile

2. 分子式：C₂₂H₁₈Cl₂N₈

3. 分子量：465.34 g/mol

4. CAS NO：252917-06-9

5. 純度：＞95%（HPLC）

6. 外觀：Off-white solid

7. 溶解性：DMSO

8. 保存和穩(wěn)定性：粉末4 °C避光保存，重溶后的儲存液分裝后-20 °C保存，6個月穩(wěn)定。

9. 質(zhì)量控制：HPLC測定純度，MS測定準確分子量，CHIR99021對小鼠胚胎干細胞的細胞毒性測試。

10. 結(jié)構圖：

訂購信息：原裝好貨，歡迎訂購，：，：。

引用文獻：

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• Ren J; Briones V; Barbour S; Yu W; Han Y; Tarashima M; Muegge K. "The ATP binding site of the chromatin remodeling homolog LSH is required for nucleosome density and de novo DNA methylation at repeat sequences." Nucl Acids Res doi: 10.1093/nar/gku1371 (2015)

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• Tan H-K; Toh C-XDl Ma D; Yang B; Liu TM; Lu J; Wong C-W; Tan T-K; Li H; SYn C; Tan E-L; Lim B; Lim Y-P; Cook SA; Loh Y-H. "Human finger-prick induced pluripotent stem cells facilitate the development of stem cell banking." Stem Cells Trans Medicine 3:586 (2014)

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— —Written/Edited by V. Shallan【版權歸MKBio懋康所有】

上海懋康生物科技有限公司是一家涉足于生命科學和生物技術領域研究的試劑、儀器和實驗室消耗品與實驗服務工作，主要從事細胞生物學、植物學、分子生物學、免疫學、生物化學、蛋白組學。生物制藥與診斷試劑研發(fā)生產(chǎn)等領域。 本公司秉承“以人為本，以誠為信、合同守信"的經(jīng)營理念。堅持"品質(zhì)保障"的原則為廣大客戶提供優(yōu)質(zhì)產(chǎn)品。

Stemolecule™ CHIR99021（GSK-3β抑制劑）

Stemolecule™ CHIR99021（GSK-3β抑制劑）

Stemolecule™ CHIR99021（GSK-3β抑制劑）